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What happens if the sample size is more than you can manage in a year? Double the treatment effect. If the sample size is too small, and you can't justify enough funding, halve the treatment effect. Usually, though it's the smallest difference that you would say is clinically important.
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Term 2, 2006 Advanced Methods in Biostatistics, II 6. Hypothesis testing sample size (single group, or paired differences) 2 β 2 2 β (Z Z ) δ σ (Z Z ) σ n ⎟ × + ⎠ ⎞ ⎜ ⎝ ⎛ = × +. /2 /2 α α. Required sample size depends inversely on the square of the effect size. Effect size = δ .
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ConsortStatement > CONSORT 2010 > Sample size
The size of effect deemed important is inversely related to the sample size necessary to detect it; that is, large samples are necessary to detect small differences. Elements of the sample size calculation are (1) the estimated outcomes in each group (which implies the clinically important target difference between the intervention groups); (2) the